Selected Publications

Legend: Corresponding author = . Trainees/lab personnel = bold.. Dr. Johnson’s unique ISI Researcher ID is B-3919-2008 (see and his citation metrics are public on Google Scholar Citations ( ).

74. Bround MJ, Asghari P, Wambolt R, Bohunek L, Smits C, Philit M, Kieffer TJ, Lakatta EG, Boheler KR, Moore EDW, Allard MF, Johnson JD. Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice. Cardiovascular Research. EPub August 6, 2012.

73. Luciani DS, White SA, Widenmaier S, Saran V, Taghizadeh F, Hu X, Allard MF, Johnson JD. Bcl-2 and Bcl-xL suppress glucose signalling in pancreatic beta-cells. Accepted in Diabetes June 26 2011.

72. Hoesli C, Johnson JD, Piret JM. 2012. Purified Human Pancreatic Duct Cell Culture Conditions Defined by Serum-Free High-Content Growth Factor Screening. PLoS ONE Feb 22, 2012.

71. Szabat M, Lynn FC, Hoffman BG, Kieffer TJ, Allan DW, Johnson JD. 2012. Maintenance of b-cell maturity and plasticity in the adult pancreas: Developmental biology concepts in adult physiology. Invited Review. Diabetes June 1, 2012.

70. Kruit J, Wijesekara N, Westwell-Roper C, Vanmierlo T, de Haan W, Bhattacharjee A, Tang R, Wellington C, LutJohann D, Johnson JD, Brunham L, Verchere CB, Hayden MR. 2012. Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation and impaired b-cell function. 61(3):659-64. Epub 2012 Feb 7.

69. Wang F, Wang Y, Zhang D, Puthanveetil P, Johnson JD, Abrahani A, Rodrigues B. 2011. Fatty acid-induced nuclear translocation of heparanase uncouples glucose metabolism in endothelial cells. Arteriosclerosis, Thrombosis and Vascular Biology 32(2):406-14. Epub 2011 Nov 23.

68. Szabat M*, Kalynyak TB*, Lim GE, Chu KY, Yang YH, Asadi A, Gage BK, Ao Z, Warnock GL, Piret JM, Kieffer TJ, Johnson JD. 2011. Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes. Cell Death and Disease. Epub Nov 24, 2011. 2:e232. doi: 10.1038/cddis.2011.119. * co-first authors.

67. Kruit JK, Wijesekara N, Manning Fox JE, Dai X-Q, Brunham LR, Searle GJ, Morgan GP, Costin AJ, Tang R, Johnson JD, Light PE, Marsh BJ, MacDonald PE, Verchere CB, Hayden MR. 2011. Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules. Diabetes 60(12):3186-96. Epub 2011 Oct 12.

66. Chu KY, Li H, Wada K, Johnson JD. 2011. Ubiquitin C-terminal hydrolase L1 is required for β-cell survival and function in lipotoxicity. Diabetologia. 285(42):32606-15. Epub 2010 Aug 7.

65. Alejandro EU, Lim GE, Mehran AE, Hu X, Taghizadeh F, Pelipeychenko D, Baccarini M, Johnson JD. 2011. Pancreatic beta-cell Raf-1 is required for glucose tolerance, insulin secretion and insulin 2 transcription. FASEB J 25(11):3884-95. Epub 2011 Aug 4.

64. Szabat M, Pourghaderi P, Soukhatcheva G, Verchere CB, Warnock GL, Piret JM, Johnson JD. 2011. Kinetics and genomic profiling of adult human and mouse β-cell maturation. Islets. Volume 3, Issue 4 July/August 2011. Pages 175 – 187. DOI: 10.4161/isl.3.4.15881.

63. Chu KY, Briggs MJL, Albrecht T, Drain PF, Johnson JD. 2011. Differential regulation and localization of carboxypeptidase D and carboxypeptidase E in human and mouse β-cells. Accepted in Islets April 7, 2011. Volume 3, Issue 4   July/August 2011. Pages 155 – 165. DOI: 10.4161/isl.3.4.15767

62. Gallo M, Park D, Luciani DS, Kida K, Palmieri F, Blacque OE, Johnson JD, Riddle DL. 2011. MISC-1/OGC links mitochondrial metabolism, apoptosis and insulin secretion. PLoS ONE February 15, 2011. 6(3):e17827.

61. Johnson JD, Bround M, White SA, Luciani DS. 2011. Nanospaces between endoplasmic reticulum and mitochondria as control centers of pancreatic β-cell metabolism and survival. Invited Review. Protoplasma. 249 Suppl 1:S49-58. Epub 2011 Nov 22.

60. Fu M, Li L, Albrecht T, Johnson JD, Kojic LD, Nabi IR. 2011. Autocrine molility factor/phosphoglucose isomerase regulates ER stress and cell death through control of ER calcium release. Cell Death and Differentiation. 18(6):1057-70. Epub Jan 21, 2011.

59. Yang YHC, Szabat M, Bragagnini C, Kott K, Helgason CD, Hoffman BG, Johnson JD. 2011. Paracrine signaling loops in adult pancreatic islets: Netrins modulate beta-cell apoptosis via Neogenin and Unc5a. 54(4):828-42. Epub 2011 Jan 7.

58. Hoesli CA, Raghuram K, Kiang R, Mocinecová D, Hu X, Johnson JD, Lacík I, Kieffer TJ, Piret JM. 2010. Pancreatic Cell Immobilization in Alginate Beads Produced by Emulsion and Internal Gelation. EPub Oct 11, 2010. Biotechnology & Bioengineering.

57. Hill JA1, Szabat M1, Hoesli CA1, Gage BK, Yang YH, Williams DE, Riedel MJ, Luciani DS, Kalynyak TB, Tsai K, Ao Z, Andersen RJ, Warnock GL, Piret JM, Kieffer TJ, Johnson JD. 2010. Multi-parameter, high-content, high-throughput screening for regulators of beta-cell fate and function. Accepted in PLoS One September 2, 2010. Sep 23;5(9):e12958. 1 co-first authors.

56. Chu KY, Lin Y, Hendel A, Kulpa JE, Brownsey RW, Johnson JD. ATP-citrate lyase reduction mediates palmitate-induced apoptosis in pancreatic beta-cells. Journal of Biological Chemistry. EPub. August 7, 2010. Oct 15;285(42):32606-15.

55. Bernal-Mizrachi E, Cras-Méneur C, Johnson JD, Permutt MA. 2010 Transgenic overexpression of active calcineurin in beta-cells results in decreased beta-cell mass and hyperglycemia in mice. PLos ONE. Aug 3;5(8):e11969

54. Szabat, M, Johnson, JD, Piret JM. 2010. Reciprocal modulation of adult beta-cell maturity by activin A and follistatin. Diabetologia. 53: 1680-9. Epub 2010 May 4.

53. Wang F, Wang Y, Kim M, Puthanveetil P, Ghosh S, Luciani DS, Johnson JD, Abrahani A, Rodrigues B. 2010. Glucose-induced endothelial heparanase secretion requires cortical and stress actin reorganization. Diabetes, 87:127-36. Epub 2010 Feb 17.

52. Hutton MJH, Soukhatcheva G, Johnson JD, Verchere CB. 2010. Role of the TLR signalling molecule TRIF in beta-cell function and glucose homeostasis. Islets. Mar-Apr;2(2):104-11.

51. Alejandro EU, Kalynyak TB, Taghizadeh T, Gwiazda KS, Rawstrom EK, Jacob KJ, Johnson JD. 2010. Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathways. Endocrinology. Epub Jan 7, 2010. 151(2):502-12.

50. Fujimoto K, Hanson PT, Tran H, Ford EL, Han Z,JohnsonJD, Levine B, Schimdt B, Wice BM,Polonsky KS. 2009. Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation. Journal of Biological Chemistry. Oct 2;284(40):27664-73. Epub 2009 Aug 4.

49. Johnson JD, Otani K, Bell GI, Polonsky KS. 2009. Impaired insulin exocytosis in transgenic mice over-expressing calpastatin in pancreatic beta-cells. lslets August 4, 2009.

48. Kewalramani G, Puthanveetil P, Wang F, Kim MS, Deppe S, Abrahani A, Luciani DS, Johnson JD, Rodrigues B. 2009. AMP-activated protein kinase confers protection against TNF-alpha induced cardiac cell death. Cardiovascular Research. Epub June 12, 2009. 84, 42-53.

47. Li J, Johnson JD. 2009. Mathematical models of subcutaneous injection of insulin analogues: A mini-review. Discrete and Continuous Dynamical Systems – Series B.12: 401-414.

46. Johnson JD, Ao Z, Ao P, Li H, Dai L, He Z, Tee M, Potter KJ, Meloche RM, Thompson DM, Verchere CB, Warnock GL. 2009. Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets. Cell Transplantation. Epub April 10, 2009. 18: 833-845.

45. Gwiazda K, Yang TB, Lin Y, Johnson JD†. 2009. Effects of palmitate on ER and cytosolic Ca2+ homeostasis in b-cells. American Journal of Physiology. Accepted Jan 10, 2009. 296: E690-E701.

44. Szabat M, Luciani DS, Piret J, Johnson JD. 2008 Maturation of adult beta-cells revealed using a Pdx1/Insulin dual reporter lentivirus. Endocrinology. Epub December 3, 2008. 150: 1627-1635

43. Warnock GL, Thompson DM, Meloche RM, Shapiro RJ, Ao Z, Keown P, Johnson JD, Verchere CB, Partovi N, Begg IS, Fung M, Kozak SE, Tong SO, Al Ghofaili KM, Harris C. 2008. A Multi-Year Analysis of Islet Transplantation Compared With Intensive Medical Therapy on Progression of Complications in Type 1 Diabetes. Transplantation. 86(12):1762-6.

42. Luciani DS, Gwiazda K, Yang TL, Kalynyak TB, Bychkivska Y, Jeffrey KD, Frey MHZ, Sampaio AV, Underhill TM, JohnsonJD. 2008. Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and b-cell death. Diabetes. E-pub. Nov 27, 2008. 58(2):422-32.

41. Johnson JD. 2008. Proteomic identification of carboxypeptidase E connects lipid-induced beta-cell apoptosis and dysfunction in type 2 diabetes. Invited review for Cell Cycle. Jan 1;8(1):38-42. Epub 2009 Jan 4.

40. Alejandro EU, Johnson JD. 2008. Raf-1 kinase in the pancreatic beta-cell. CellSciences. Published Online Oct 2008. Invited review.

39. Chang JP, Johnson JD, Sawisky GR, Grey CL, Mitchell G, Booth M, Volk MM, Parks SK, Thomson E, Goss GG, Klausen C, Habibi HR. 2009. Signal transduction in multifactorial neuroendocrine control of gonadotropin secretion and synthesis in teleosts – studies on the goldfish model. (Invited Review) General and Comparative Endocrinology. E-pub Sept 21. Mar;161(1):42-52.

38. Walia P, Asadi A, Kieffer TJ, Johnson JD, Chanoine J-P. 2009. Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach. Pediatric Research. E-pub Sept 3. Jan;65(1):39-44.

37. Wang Y, Huang B, Luciani DS, Wang X, JohnsonJD, Proud CG. 2008. Rheb activates protein synthesis and growth in adult rat cardiomyocytes. Journal of Molecular and Cellular Cardiology. 45: 812-20. Epub 2008 Aug 3.       

36. Jeffrey KD, Alejandro EU, Luciani DS, Kalynyak TB, Hu X, Li H, Lin Y, Townsend RR, Polonsky KS, Johnson JD. 2008. Carboxypeptidase E mediates palmitate-induced beta-cell ER-stress and apoptosis. Proc. Natl. Acad. Sci. USA. (Track II). Jun 17;105(24):8452-7. Epub 2008 Jun 11.

35. Johnson JD, Alejandro EU. 2008. Control of Pancreatic Beta-cell Fate by Insulin Signaling: The Sweet Spot Hypothesis.  Cell Cycle. Invited review. EPub. March 3, 2008. May 15;7(10):1343-7.       

34. Dror V, Kalynyak TB, Bychkivska Y, Frey MHZ, Tee M, Jeffrey KD, Nguyen V, Luciani DS, Johnson JD. 2008. Glucose and ER channels regulate HIF1b via presenilin1 in pancreatic b-cells. Journal of Biological Chemistry. EPub Jan 4, 2008. 283:9909-16. My role – designed all experiments, performed 30% of experiments, and wrote the manuscript. IF5.8/C17.     

33. Beith JL, Alejandro EU, Johnson JD. 2008. Insulin stimulates primary β-cell proliferation via raf-1 kinase. Endocrinology. 149:2251-60.     

32. Alejandro EU, Johnson JD. 2008. Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic b-cell apoptosis. Journal of Biological Chemistry. Jan 25;283(4):2407-17. Epub 2007 Nov 15.     

31. Dror V, Nguyen V, Walia P, Kalynyak TB, Hill JA, Johnson JD. 2007. Notch signalling suppresses apoptosis in adult pancreatic islet cells. Diabetologia 50:2504-15.

30. Luciani DS, Ao P, Hu X, Warnock GL, Johnson JD. 2007. Voltage-gated Ca2+ influx and insulin secretion in human and mouse beta-cells are impaired by the mitochondrial Na+/Ca2+ exchange inhibitor CGP-37157. European Journal of Pharmacology. 576:18-25.

29. Warnock GL, Liao T, Wang X, Ou D, Ao Z, Johnson JD, Verchere CB, Thompson D. 2007. An Odyssey of Islet Transplantation for Therapy of Type 1 Diabetes. World Journal of Surgery. Aug;31(8):1569-76. Epub 2007 Jun 12.

28. Johnson JD. 2007. Pancreatic β-cell apoptosis in maturity onset diabetes of the young. (Invited review). Canadian Journal of Diabetes. 31:67-74.

27. Brunham LR, Kruit JK, PapeTD, Timmins JM, ReuwerAQ, Vasanji Z, MarshBJ, Johnson JD, Parks JS, VerchereCB, HaydenMR. 2007. b-Cell ABCA1 Influences Insulin Secretion, Glucose Homeostasis and Response to Thiazolidinedione Treatment. Nature Medicine. 13: 230-7. Published online February 18.     

26. JohnsonJD, Bernal-MizrachiE, AlejandroE, HanZ, KalynyakT, LiH, Beith JL, Gross J, WarnockGL, TownsendRR, Permutt MA, Polonsky KS. 2006. Insulin protects islets from apoptosis via pdx-1 and specific changes in the human islet proteome. Proc. Natl. Acad. Sci. USA. (Track II).103: 19575-80.     

25. JohnsonJD, Bernal-MizrachiE, FordEL, HanZ, KusserKL, Luciani DS, TranH, Randall TD, LundFE, Polonsky KS. 2006. Suppressed insulin signaling and increased apoptosis in Cd38 null islets. Diabetes. 55: 2737-2746.

24. Wideman RD, Yu ILY, Webber TD, C. Verchere CB, Johnson JD, Cheung AT, Kieffer TJ. 2006. Improving Function and Survival of Pancreatic Islets by Endogenous Production of GLP-1. Proc. Natl. Acad. Sci. USA. (Track II). 103: 13468–13473.      

23. Luciani DS, JohnsonJD. 2005. Acute effects of insulin on dispersed cells from transplantable human islets. Molecular and Cellular Endocrinology. 241: 88-98.

22. Warnock GL, Meloche RM, Thompson D, Shapiro J, Fung M, Ao Z, Ho S, He Z, Dai LJ, Young L, Blackburn L, Kozak S, Kim P, Al-Adra D, Johnson JD, Liao T, Elliott T, Verchere CB. 2005. Improved human pancreatic islet isolation for a prospective cohort study of islet transplantation vs best medical therapy in type 1 diabetes mellitus. Archives of Surgery. 140:735-44.

21. Johnson JD, Chang JP. 2005. Calcium buffering activity of mitochondria controls basal growth hormone secretion and modulates specific neuropeptide signaling. Cell Calcium. 37:573-81.

20. Ohsugi M, Cras-Méneur C, Zhou Y, Bernal-Mizrachi E, Johnson JD, Luciani DS, Polonsky KS, Permutt MA. 2005. Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content and secretion. Journal of Biological Chemistry. 280, 4992-5003.

19. Bernal E, Fatrai S, Johnson JD, Ohsugi M, Otani K, Han Z, Polonsky KS, PermuttMA. 2004. Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced AKT activity in pancreatic islet beta-cells. Journal of Clinical Investigation. 114: 928-936.

18. Johnson JD, HanZ, OtaniK, YeH, Zhang Y, Wu H, Horikawa Y, Misler S, BellGI, Polonsky KS. 2004. RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets. Journal of Biological Chemistry 279: 24794-24802.

17. Johnson JD, Kuang S, Misler S, Polonsky KS. 2004. Ryanodine receptors in human pancreatic beta-cells: Localization and effects on insulin secretion. FASEB J. 10.1096/fj.03-1280fje.

16. Johnson JD, Ahmed NT, Luciani DS, HanZ, TranH, FujitaJ, Misler S, Edlund H, Polonsky KS. 2003. Increased islet apoptosis in PDX-1+/- mice. Journal of Clinical Investigation. 111:1147-1160.

15. Koster JC, Remedi M, Flagg T, Johnson JD, Markova K, Marshall BA, Nichols CG. 2002. Hyperinsulinism induced by targeted suppression of beta cell KATP channels. Proc. Natl. Acad. Sci. USA. (Track II). 99:16992-7.

14. Johnson JD, Klausen C, Habibi HR, Chang JP. 2003. A GnRH-insensitive, thapsigargin-sensitive Ca2+ store reduces basal gonadotropin exocytosis and gene expression: Comparison with agonist-sensitive Ca2+ stores. J Neuroendocrinology 15:204-14.

13. Johnson, JD, Misler S. 2002. Nicotinic acid adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human b-cells. Proc. Natl. Acad. Sci. USA (Track II). 99: 14566-14571.

12. Johnson JD, Chang JP. 2002. Agonist-specific and sexual stage-dependent inhibition of GnRH-stimulated gonadotropin and growth hormone release by ryanodine: Relationship to sexual stage-dependent caffeine-sensitive hormone release. J Neuroendocrinology 14: 144-155.

11. Johnson JD, Klausen C, Habibi HR, Chang JP. 2002. Function-specific Ca2+ stores selectively regulate growth hormone secretion, storage and mRNA. Am J Physiol. Endo. 282: E810-E819. My role – Designed and performed 90% of the experiments and wrote manuscript. IF4.4/C16.

10. Johnson JD, Wong CJH, Yunker WK, Chang JP. 2001. Caffeine stimulated GTH-II release involves Ca2+ stores with novel properties. Am J Physiol. Cell 282: C635-C645.

9. Wong CJH, Kwong P, Johnson JD, Yunker WK, Chang JP. 2001. Modulation of GTH-II release by K+ channel blockers in goldfish gonadotropes: a novel stimulatory action of 4-aminopyridine J Neuroendocrinol.13: 915-958.

8. Chang JP, Wirachowsky NR, Kwong P, Johnson JD. 2001. PACAP stimulation of gonadotropin-II secretion in goldfish pituitary cells: mechanisms of action and interaction with gonadotropin-releasing hormone. J Neuroendocrinology, 13: 540-550.

7. Wong CJH, Johnson JD*, Yunker WK, Chang JP. 2001. Caffeine stores and dopamine differentially require Ca2+ channels to stimulate hormone secretion. Am J Physiol Integrative 280: R494-R503. * co-first author.

6. Wirachowsky NR, Kwong P, Yunker WK, Johnson JD, Chang JP. 2000. Mechanisms of action of pituitary adenylate cyclase-activating polypeptide (PACAP) on growth hormone release from dispersed goldfish pituitary cells. Fish Physiology Biochemistry 23: 201-214.

5. Johnson JD, Van Goor F, Jobin, RM, Wong CJH, Chang JP. 2000. Agonist-specific Ca2+ signaling systems, composed of multiple intracellular Ca2+ stores, regulate gonadotropin secretion. Molecular and Cellular Endocrinology 170: 15-29.

4. Johnson, JD, Chang, JP. 2000. Novel, thapsigargin-insensitive intracellular Ca2+ stores control growth hormone release from goldfish pituitary cells. Molecular and Cellular Endocrinology. 165: 139-150.

3. Chang JP, Johnson JD, Van Goor F, Wong CJH, Yunker WK, Uretsky AD, Jobin RM, Wong AOL, Goldberg JI. 2000. Signal transduction mechanisms mediating secretion in goldfish gonadotropes and somatotropes. Biochemistry and Cell Biology. 78: 139-153.

2. Johnson JD, Chang JP. 2000. Function- and agonist-specific Ca2+ signalling: the requirement for and mechanism of spatial and temporal complexity in Ca2+ signals. Biochemistry & Cell Biology 78: 217-240.

1. Johnson JD, Van Goor F, Wong CJH, Goldberg JI, Chang JP. 1999. Two endogenous gonadotropin-releasing hormones generate dissimilar Ca2+ signals in identified goldfish gonadotropes. General & Comparative Endocrinology. 116: 178-191.

Book Chapters

1. Chang JP, Van Goor F, Lo A, Johnson JD,  Jobin RM, Goldberg JI. 1997. Pickford Medal Plenary Lecture: Signal transduction of gonadotropin (GTH)-II secretion in goldfish pituitary cells. In Advances in Comparative Endocrinology. S. Kawashima (Eds.) Monduzzi, Bologna. 19: 29-33.

2. Luciani DS, Johnson JD. 2009. Pancreatic Beta-cell Apoptosis. In. Modern Insights Into Disease From Molecules to Man: Apoptosis. V. R. Preedy (Ed). Science Publishers.

3. Johnson JD, Luciani DS. 2010. Mechanisms of Pancreatic Beta-cell Apoptosis in Diabetes and its Therapies. In. Advances in Experimental Medicine and Biology: The Islets of Langerhans. S. Islam (Ed). Springer. 654:447-62. Citations = 11.

4. Wang X, Ou D, Ao Z, Verchere CB, Meloche M, Johnson JD, Mui A, Warnock GL. 2009. Hope and challenges for islet transplantation in the treatment of type 1 diabetes. In. Handbook of Type 1 Diabetes Mellitus: Etiology, Diagnosis, and Treatment. NOVA.



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