Selected publications
Tung CC, Lobo PA, Kimlicka L, Van Petegem F (2010) The N-terminal disease hot spot of Ryanodine Receptors forms a cytoplasmic vestibule. Nature. 468, 585-588.
Lobo PA, Van Petegem F (2009). Crystal structures of the N-terminal domains of cardiac and skeletal muscle ryanodine receptors: insights into disease mutations. Structure, 17,1505-1514.
Van Petegem F, Duderstadt KE, Clark KA, Wang M, Minor DL (2008). Alanine-scanning mutagenesis defines a conserved energetic hotspot in the CaVα AID-CaVβ interaction site that is critical for channel modulation. Structure, 16, 280-294.
Van Petegem F, Chatelain FC, Minor DL (2005) Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex. Nature Struct. Mol. Biol., 12, 1108-1115
Van Petegem F, Clark KA, Chatelain FC, Minor DL Jr. (2004) Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain. Nature 429, 671-675.
All Publications by F. Van Petegem
2010
Tung CC, Lobo PA, Kimlicka L, Van Petegem F (2010) The N-terminal disease hot spot of Ryanodine Receptors forms a cytoplasmic vestibule. Nature. 468, 585-588.
Kim EY, Rumpf CH, Van Petegem F, Arant RJ, Findeisen F, Cooley ES, Isacoff EY, Minor DL Jr. (2010) Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization. EMBO J. In Press
Okamoto S, Van Petegem F, Patrauchan MA, Eltis LD (2010) AnhE, a metallochaperone involved in the maturation of a cobalt-dependent nitrile hydratase. J Biol Chem. 285, 25126-25133.
Janssens ME, Geysen D, Broos K, De Goeyse I, Robbens J, Van Petegem F, Timmermans J-P, Guisez Y (2010) Folding properties of the hepatitis B core as a carrier protein for vaccination research. Amino Acids. 38(5), 1617-1626.
2009
Cheung TYS, Fairchild M, Zarivach R, Tanentzapf G, Van Petegem F (2009) Crystal Structure of the Talin Integrin Binding Domain 2. J. Mol. Biol. 387, 787-793.
Sarhan MS, Van Petegem F, Ahern CA (2009). A double tyrosine motif in the cardiac sodium channel Domain III-IV linker couples calcium dependent calmodulin binding to inactivation gating. J Biol Chem, 284, 33265-33274
Lobo PA, Van Petegem F (2009). Crystal structures of the N-terminal domains of cardiac and skeletal muscle ryanodine receptors: insights into disease mutations. Structure, 17,1505-1514.
2008
De Vos D, Xu Y, Aerts T, Van Petegem F, Van Beeumen JJ (2008). Crystal structure of Sulfolobus acidocaldarius aspartate carbamoyltransferase in complex with its allosteric activator CTP. Biochem Biophys Res Commun., 372, 40-44
Kim EY, Rumpf CH, Fujiwara Y, Cooley ES, Van Petegem F, Minor DL (2008). Structures of CaV2 Ca2+/CaM-IQ domain complexes reveal binding modes that underlie calcium-dependent inactivation and facilitation. Structure, 16, 1455-1467.
Van Petegem F, Duderstadt KE, Clark KA, Wang M, Minor DL (2008). Alanine-scanning mutagenesis defines a conserved energetic hotspot in the CaVα AID-CaVβ interaction site that is critical for channel modulation. Structure, 16, 280-294.
2005-2007
Van Petegem F, De Vos D, Savvides S, Vergauwen B, Van Beeumen J (2007). Understanding nicotinamide dinucleotide cofactor and substrate specificity in class I flavoprotein disulfide oxidoreductases: Crystallographic analysis of a glutathione amide J. Mol. Biol., 374, 883-889
Van Petegem F, Minor DL (2006). The structural biology of voltage-gated calcium channel function and regulation. Biochem. Soc. Trans, 34, 887-893.
Van Petegem F, Chatelain FC, Minor DL (2005) Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex. Nature Struct. Mol. Biol., 12, 1108-1115
2003-2004
Van Petegem F, Clark KA, Chatelain FC, Minor DL Jr. (2004) Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain. Nature 429, 671-675.
Dumortier C, Fitch J, Van Petegem F, Vermeulen W, Meyer TE, Van Beeumen J, Cusanovich MA. (2004) Protein dynamics in the region of the sixth ligand methionine revealed by studies of imidazole binding to Rhodobacter capsulatus cytochrome c2 hinge mutants. Biochemistry, 43, 7717-7724.
De Vos D, Van Petegem F, Remaut H, Legrain C, Glansdorff N, Van Beeumen J. (2004) Crystal structure of T state aspartate carbamoyltransferase of the hyperthermophilic archaeon Sulfolobus acidocaldarius. J. Mol. Biol. 339, 887-900.
Aghajari N, Van Petegem F, Villeret V, Chessa JP, Gerday C, Haser R, and Van Beeumen J. (2003). Crystal structures of a psychrophilic metalloprotease provide new insights into catalysis by cold-adapted proteases. Proteins: Struct. Funct. Genet. 50, 636-647.
2000 – 2002
Van Petegem F, Collins T, Meuwis MA, Gerday C, Feller G, and Van Beeumen J (2002). The structure of a cold-adapted family 8 xylanase at 1.3 Å resolution, structural adaptations to cold and investigation of the active site. J. Biol. Chem., 278, 7531-7539
Van Petegem F, Vandenberghe I, Bhat MK, and Van Beeumen J (2002). Atomic resolution structure of the major endoglucanase from normal Thermoascus aurantiacus. Biochem. Biophys. Res. Commun. 296, 161-166.
Van Petegem F, Collins T, Meuwis MA, Gerday C, Feller G, and Van Beeumen J (2002). Crystallization and preliminary X-ray analysis of a xylanase from the psychrophile Pseudoalteromonas haloplanktis. Acta Cryst. D., 58, 1494-1496.
Vergauwen B, Van Petegem F, Remaut H, Pauwels F, and Van Beeumen J (2002). Crystallization and preliminary X-ray crystallographic analysis of glutathione amide reductase from Chromatium gracile. Acta Cryst. D., 58, 339-340.
Van Petegem F, Contreras H, Contreras R, and Van Beeumen J (2001). Trichoderma reesei alpha-1,2-mannosidase: structural basis for the cleavage of four consecutive mannose residues. J. Mol. Biol., 312, 157-165.
Georlette D, Jonsson ZO, Van Petegem F, Chessa J, Van Beeumen J, Hubscher U, Gerday C (2000). A DNA ligase from the psychrophile Pseudoalteromonas haloplanktis gives insights into the adaptation of proteins to low temperatures. Eur. J. Biochem. 267, 3502-3512.
