WHAT WE DO
The influx of Ca2+ through Ca2+ selective channels drives the contraction of cardiac and skeletal muscle, and release of hormones and neurotransmitter. We study how these Ca2+ channels function, how they are regulated by different signalling events, and how disease mutations lead to channel malfunction. We employ a combination of structural biology, electrophysiology, and various biophysical methods.
LATEST NEWS: THE STRUCTURE OF THE RYANODINE RECEPTOR N-TERMINAL DISEASE HOT SPOT
Reference: Tung et al, Nature (2010) DOI 10.1038/nature09471.
Check out the video: CPVT mutations
WHERE WE ARE
We are located in beautiful Vancouver, British Columbia, Canada at the University of British Columbia.
Our lab is within the Department of Biochemistry and Molecular Biology, and part of the Cardiovascular Research Group, located within the new Life Sciences Centre.
